49ers vs. Cardinals odds: Opening lines for Week 3 matchup

The San Francisco 49ers have won and covered in both games so far. From a point-spread perspective, neither game has been particularly close.

For the second week in a row, the 49ers are home favorites by more than a touchdown. This time, it's against a division opponent. At FanDuel Sportsbook, the Niners are 8.5-point favorites, with the total set at 47.5.