49ers will face significant adversity ahead of Week 1
49ers will face significant adversity ahead of Week 1
INDIANAPOLIS, IN - DECEMBER 22: Head Coach Kyle Shanahan of the San Francisco 49ers in the locker room before the game against the Indianapolis Colts at Lucas Oil Stadium on December 22, 2025 in Indianapolis, Indiana. The 49ers defeated the Colts 48-27. (Photo by Michael Zagaris/San Francisco 49ers/Getty Images) | Getty Images JB ScottSat, July 25, 2026 at 8:00 PM UTC·1 min read
